SCHEMBL8710220

SCHEMBL8710220

[CH]=Cc1ccc(CCCC)cc1O[SiH](C)C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SKP2 Q13309 1/20 0.37
NPC1 O15118 1/20 0.37
HPGD P15428 1/20 0.37
MAPK1 P28482 1/20 0.37
HTT P42858 1/20 0.37
RAB9A P51151 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
PPARG P37231 1/20 0.36
PPARA Q07869 1/20 0.36
PSMB5 P28074 1/20 0.35
LTA4H P09960 2/20 0.34
CYP1A2 P05177 2/20 0.34
CYP2D6 P10635 2/20 0.34
LMNA P02545 1/20 0.34
TUBB4A P04350 1/20 0.34
TUBB P07437 1/20 0.34
TUBA3C P0DPH7 1/20 0.34
TSHR P16473 1/20 0.34
TUBA1B P68363 1/20 0.34
TUBA4A P68366 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7926899 0.85 CDK1 (0.40) SKP2HPGDPPARGPPARAPSMB5
SCHEMBL4872798 0.77 SKP2 (0.40) SKP2NPC1HPGDMAPK1HTT
SCHEMBL8893416 0.68 PPARA (0.42) NPC1HPGDRAB9APPARGPPARA
SCHEMBL31455942 0.68 ALDH1A1 (0.53) PPARGPPARALTA4HCYP1A2CYP2D6
SCHEMBL8704610 0.66 SKP2 (0.38) SKP2NPC1HPGDMAPK1HTT
SCHEMBL2759507 0.65 ATM (0.63) PPARGPPARALTA4HCYP1A2CYP2D6
SCHEMBL28038475 0.65 PPARA (0.51) PPARGPPARA
SCHEMBL9830751 0.64 GRIN2D (0.49) HPGDCYP2D6LMNAHIF1ACYP3A4
SCHEMBL10534647 0.64 THRB (0.46) SKP2NPC1HPGDMAPK1HTT
SCHEMBL15944034 0.64 CALM1 (0.54) SKP2MAPK1CYP1A2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0540854-B1 Preparation for promoting hair growth SANSHO SEIYAKU KK (JP) 1998-01-21 EP disclosed
US-5656264-A ADMINISTERING TO THE SCALP OF THE MALE A PREPERATION CONSITING OF 6-BENZYLAMINOPURINE SANSYO SEIYAKU CO., LTD. (JP) 1997-08-12 US disclosed
EP-0540854-A2 Preparation for promoting hair growth Sansho Seiyaku Co., Ltd. (JP) 1993-05-12 EP disclosed