Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.59 |
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714772 | 0.84 | KMT2A (0.69) | MAPTNPC1KDM4ELMNARAB9A | |
| SCHEMBL30821443 | 0.82 | MAPK10 (0.67) | MAPTNPC1KDM4ELMNARAB9A | |
| SCHEMBL7748143 | 0.79 | MAPK10 (0.65) | MAPTNPC1KDM4ELMNARAB9A | |
| SCHEMBL5666106 | 0.75 | ALDH1A1 (0.60) | MAPTKDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL7367686 | 0.75 | RORC (0.63) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL16728064 | 0.75 | KMT2A (0.74) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL4743658 | 0.74 | NPC1 (0.68) | MAPTNPC1KDM4ELMNARAB9A | |
| SCHEMBL3191246 | 0.74 | NPC1 (1.00) | MAPTNPC1KDM4ELMNARAB9A | |
| SCHEMBL7377084 | 0.74 | ALDH1A1 (0.71) | MAPTNPC1KDM4ELMNARAB9A | |
| SCHEMBL5049650 | 0.74 | PKM (0.45) | MAPTNPC1KDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |