Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045832 | 0.97 | LMNA (0.42) | LMNAALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL8050306 | 0.94 | LMNA (0.41) | LMNAALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL8046147 | 0.87 | ALDH1A1 (0.42) | LMNAALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL8048583 | 0.83 | ALDH1A1 (0.45) | LMNAALDH1A1HTTMAPK1SMN1; SMN2 | |
| SCHEMBL8711210 | 0.82 | HTT (0.41) | LMNAALDH1A1MAPTHTTHSD17B10 | |
| SCHEMBL8042146 | 0.81 | KDM4E (0.42) | LMNAMAPTHTTSMN1; SMN2RAB9A | |
| SCHEMBL8043207 | 0.80 | MAPT (0.44) | LMNAALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL8043763 | 0.79 | ALDH1A1 (0.40) | LMNAALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL8047667 | 0.79 | LMNA (0.40) | LMNAALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL8041897 | 0.79 | ALDH1A1 (0.47) | LMNAALDH1A1MAPTHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |