Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045085 | 0.86 | POLB (0.43) | ALDH1A1NPSR1USP2POLBLMNA | |
| SCHEMBL8050306 | 0.84 | LMNA (0.41) | ALDH1A1NPSR1POLBLMNATSHR | |
| SCHEMBL8044497 | 0.83 | HTT (0.33) | ALDH1A1OPRK1POLBMAPTKDM4E | |
| SCHEMBL8032734 | 0.82 | ALDH1A1 (0.37) | ALDH1A1NPSR1USP2POLBMAPT | |
| SCHEMBL8045832 | 0.82 | LMNA (0.42) | ALDH1A1OPRK1POLBLMNATSHR | |
| SCHEMBL8044430 | 0.81 | CTSS (0.34) | ALDH1A1POLBLMNAMAPTKDM4E | |
| SCHEMBL8037022 | 0.80 | HTT (0.38) | ALDH1A1NPSR1POLBLMNAMAPT | |
| SCHEMBL8713674 | 0.79 | LMNA (0.40) | ALDH1A1USP2LMNATSHRMAPK1 | |
| SCHEMBL8048771 | 0.79 | MAPT (0.37) | ALDH1A1LMNAMAPK1MAPTKDM4E | |
| SCHEMBL8043192 | 0.79 | ALDH1A1 (0.35) | ALDH1A1USP2POLBLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |