Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715464 | 0.84 | TLR7 (0.43) | TLR7MEN1KMT2AEGLN2FTO | |
| SCHEMBL8709883 | 0.80 | HSD17B14 (0.56) | MEN1KMT2AGRM4HSD17B14ALDH1A1 | |
| SCHEMBL8654976 | 0.80 | FTO (0.45) | TLR7EGLN2FTOSPRKDM4E | |
| SCHEMBL8709617 | 0.80 | GRM4 (0.41) | TLR7MEN1KMT2APDE4BPDE4D | |
| SCHEMBL8712344 | 0.80 | GRM4 (0.41) | TLR7MEN1KMT2AEGLN2FTO | |
| SCHEMBL27411540 | 0.79 | PDK1 (0.41) | GRM4GRM5MALT1 | |
| SCHEMBL8709365 | 0.78 | GRM4 (0.37) | TLR7MEN1KMT2APDE4BPDE4D | |
| SCHEMBL8713994 | 0.78 | P2RX7 (0.40) | MEN1KMT2APDE4BPDE4DGRM4 | |
| SCHEMBL4707490 | 0.77 | RORB (0.50) | TLR7KMT2AEGLN2FTOGRM4 | |
| SCHEMBL8709623 | 0.76 | NPC1 (0.52) | MEN1KMT2AEGLN2FTOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |