SCHEMBL8716727

SCHEMBL8716727

CN1C(=O)C(NC(=O)/C=C/C2=CC=C(Cl)[C@H](Cl)C2)=NC(c2ccccc2)c2ccccc21

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CCKAR P32238 1/20 0.31
CCKBR P32239 1/20 0.31
KCNH2 Q12809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9869234 0.68 CCKBR (0.41) CCKARCCKBR
SCHEMBL7087130 0.67 KCNH2 (0.49) KCNH2
SCHEMBL9726866 0.62 LRRK2 (0.41) KCNH2
SCHEMBL1868702 0.59 SETDB1 (0.40) CCKBR
SCHEMBL6920408 0.57 CHEK1 (0.36) KCNH2
SCHEMBL9704603 0.57 OPRK1 (0.42) KCNH2
Hydrochloric Acid SCHEMBL7208149 0.57 CHEK1 (0.36) KCNH2
SCHEMBL18319348 0.53 LMNA (0.37)
SCHEMBL4989074 0.52 TSHR (0.65) KCNH2
SCHEMBL30746803 0.52 TSHR (0.65) KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817658-A ADMINISTERING A DIAZEPINE COMPOUND; DISEASES OF THE EAR MERCK & COMPANY, INC. (US) 1998-10-06 US disclosed