Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845312 | 0.91 | GAA (0.60) | GAAPABPC1TSHRKMT2AMEN1 | |
| SCHEMBL874313 | 0.91 | MAPK1 (0.50) | GAATSHRKMT2AMEN1LMNA | |
| SCHEMBL873465 | 0.90 | KDM4E (0.47) | GAAPABPC1TSHRKDM4ELMNA | |
| SCHEMBL873862 | 0.88 | ALDH1A1 (0.45) | GAAPABPC1TSHRKDM4ELMNA | |
| SCHEMBL871771 | 0.88 | PABPC1 (0.44) | GAAPABPC1TSHRKMT2AMEN1 | |
| SCHEMBL10119619 | 0.85 | MAPK1 (0.46) | GAAKMT2AMEN1LMNAMAPK1 | |
| SCHEMBL874324 | 0.85 | MAPK1 (0.42) | GAAPABPC1LMNAMAPK1CYP2C9 | |
| SCHEMBL874056 | 0.85 | TRPV1 (0.42) | TSHRKMT2AMEN1L3MBTL1MAPK1 | |
| SCHEMBL845518 | 0.84 | GAA (0.52) | GAAPABPC1TSHRKMT2AMEN1 | |
| SCHEMBL872886 | 0.83 | KDM4E (0.52) | GAAPABPC1TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |