Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.50 |
| ▸ | MMP12 | P39900 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | ICMT | O60725 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | GRN | P28799 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722961 | 0.85 | CA2 (0.46) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL8726202 | 0.85 | CA2 (0.46) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL8722086 | 0.80 | CA2 (0.42) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL8722158 | 0.80 | CA2 (0.41) | MMP2MMP9MMP12CA2CA1 | |
| SCHEMBL8722080 | 0.79 | MMP2 (0.55) | MMP2MMP9MMP12CA2CA1 | |
| SCHEMBL2249549 | 0.79 | MMP12 (0.60) | MMP2MMP9MMP12CA2CA1 | |
| SCHEMBL2249554 | 0.79 | CA2 (0.63) | MMP2MMP9CA2CA1ICMT | |
| SCHEMBL27517605 | 0.79 | ALDH1A1 (0.57) | MMP2MMP9MMP12CA2CA1 | |
| SCHEMBL8726191 | 0.79 | CA2 (0.41) | MMP2CA2CA1CA12CA9 | |
| SCHEMBL714972 | 0.77 | CA2 (0.61) | CA2CA1CA12CA9FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998035982-A1 | COMPOUNDS FOR USE IN ADEPT | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |