Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 3/20 | 0.46 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.44 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.44 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 14/20 | 0.46 |
| ▸ | HTR1B | P28222 | 11/20 | 0.46 |
| ▸ | HTR1F | P30939 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8725912 | 1.00 | HTR1D (0.46) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8723856 | 0.95 | HTR1D (0.50) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8725928 | 0.88 | RORC (0.47) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL8720774 | 0.84 | L3MBTL3 (0.43) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8720776 | 0.84 | HRH3 (0.47) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| SCHEMBL8724094 | 0.83 | ACKR3 (0.39) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8721836 | 0.82 | TMIGD3 (0.41) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8721858 | 0.82 | MAPT (0.42) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8723979 | 0.81 | MAPT (0.41) | HTR1DHTR1BHTR1AHTR1FMAPT | |
| Fumaric Acid SCHEMBL8721213 | 0.80 | HRH3 (0.42) | DRD2MAPTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0875513-A1 | Substituted heteroaromatic 5-HT 1F agonists | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |