Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | ME3 | Q16798 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.37 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728722 | 0.88 | USP28 (0.40) | SMN1; SMN2HSP90AA1HSP90AB1ME3L3MBTL3 | |
| SCHEMBL8725144 | 0.87 | HSP90AA1 (0.40) | SMN1; SMN2HSP90AA1HSP90AB1ME3L3MBTL3 | |
| SCHEMBL8726110 | 0.84 | USP28 (0.40) | SMN1; SMN2ME3L3MBTL3L3MBTL1USP28 | |
| SCHEMBL13380458 | 0.82 | MAPT (0.54) | SMN1; SMN2HSP90AA1HSP90AB1ME3L3MBTL3 | |
| SCHEMBL8725147 | 0.82 | ADRB1 (0.46) | SMN1; SMN2HSP90AA1HSP90AB1L3MBTL3L3MBTL1 | |
| SCHEMBL22837858 | 0.81 | HSP90AA1 (0.40) | SMN1; SMN2HSP90AA1HSP90AB1ME3L3MBTL3 | |
| SCHEMBL5537556 | 0.81 | ME3 (0.52) | SMN1; SMN2HSP90AA1HSP90AB1ME3NPY2R | |
| SCHEMBL5537549 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2HSP90AA1HSP90AB1ME3L3MBTL3 | |
| SCHEMBL13798544 | 0.80 | CHRNA7 (0.50) | SMN1; SMN2HSP90AA1HSP90AB1ME3L3MBTL3 | |
| SCHEMBL5535481 | 0.79 | HSP90AA1 (0.41) | SMN1; SMN2HSP90AA1HSP90AB1ME3L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5681954-A | HAS CALMODULIN INHIBITORY ACTIVITY; USEFUL IN TREATING DISEASES OF THE CIRCULATORY ORGANS OR IN CEREBRAL REGION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0624584-A1 | Piperazine derivatives useful as calmodolin inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-11-17 | — | — | EP | disclosed |