Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | EP300 | Q09472 | 6/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 6/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 12/20 | 0.40 |
| ▸ | PFKFB1 | P16118 | 11/20 | 0.40 |
| ▸ | PFKFB2 | O60825 | 9/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844922 | 0.91 | EP300 (0.48) | DPP4EP300CREBBP | |
| SCHEMBL872886 | 0.79 | KDM4E (0.52) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL844873 | 0.78 | NPC1 (0.63) | DPP4 | |
| SCHEMBL10119687 | 0.78 | CYP2C9 (0.44) | DPP4EP300CREBBPPFKFB3PFKFB1 | |
| SCHEMBL873223 | 0.78 | RHOC (0.43) | DPP4 | |
| SCHEMBL845510 | 0.78 | SCN3A (0.54) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL845110 | 0.77 | ALDH1A1 (0.48) | PFKFB3PFKFB1PFKFB2 | |
| SCHEMBL10119592 | 0.77 | F2 (0.43) | — | |
| SCHEMBL874324 | 0.77 | MAPK1 (0.42) | EP300CREBBP | |
| SCHEMBL874056 | 0.76 | TRPV1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |