Water

Water

SCHEMBL8733652

C1CCC2OC2C1.O

nearest known ligand 0.00

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Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12334971 0.96 ALDH1A1 (0.36)
SCHEMBL3219 0.96
SCHEMBL272959 0.96
SCHEMBL14844281 0.96
SCHEMBL2183062 0.96
SCHEMBL27491381 0.96 ALDH1A1 (0.36)
SCHEMBL12203926 0.96
SCHEMBL7933931 0.96
SCHEMBL23934877 0.92 ALDH1A1 (0.33)
SCHEMBL12335159 0.92 ALDH1A1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1896118-A Sodium crown ether Salen Schief base isobi-metal condensation complex, its preparation and use XIBEI NORMAL UNIV (CN) 2007-01-17 CN claimed
CN-1023217-C Process for producing phenols MITSUI PETROCHEMICAL IND (JP) 1993-12-22 CN claimed
CN-1033618-A Produce the method for phenol MITSUI PETROCHEMICAL IND (JP) 1989-07-05 CN claimed
CN-102442895-B Method for synthesizing cyclohexenone from cyclohexene JIANGSU YANGNONG CHEMICAL GROUP CO LTD 2015-04-08 CN disclosed
CN-102962099-A Preparation method of attapulgite immobilized salicylidene schiff base Co&lt;2+&gt; and Mn&lt;2+&gt; complex oxidation catalyst HUAIYIN TEACHER COLLEGE 2013-03-13 CN disclosed
CN-101966464-B Supported nano gold catalyst for cyclohexene oxidation and preparation method thereof UNIV ZHEJIANG 2012-06-06 CN disclosed
CN-102442895-A Method for synthesizing cyclohexenone by using cyclohexene JIANGSU YANGNONG CHEMICAL GROUP CO LTD 2012-05-09 CN disclosed
CN-102071229-A Method for epoxidizing cyclohexene by using enzymatic molecular oxygen DALIAN CHEMICAL PHYSICS INST 2011-05-25 CN disclosed
CN-101966464-A Supported nano gold catalyst for cyclohexene oxidation and preparation method thereof UNIV ZHEJIANG 2011-02-09 CN disclosed
CN-101804347-A Preparation method and purpose of supported nano-gold catalyst for cyclohexene oxide UNIV ZHEJIANG 2010-08-18 CN disclosed
CN-100460444-C Sodium crown ether Salen Schief base isobi-metal condensation complex, its preparation and use UNIV NORTHWEST NORMAL (CN) 2009-02-11 CN disclosed
CN-1896118-A Sodium crown ether Salen Schief base isobi-metal condensation complex, its preparation and use XIBEI NORMAL UNIV (CN) 2007-01-17 CN disclosed
CN-1344302-A Radiation curable water based cationic inks and coatings SUN CHEMICAL CORP (US) 2002-04-10 CN disclosed
EP-0645363-B1 PROCESS FOR PRODUCING ADIPIC ACID ASAHI CHEMICAL IND (JP) 1998-06-24 EP disclosed
US-5455375-A Hydrating cyclohexene oxide to 1,2-dihydroxycyclohexane and oligomers, followed by oxidation in nitric acid aolution ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1995-10-03 US disclosed
EP-0645363-A1 PROCESS FOR PRODUCING ADIPIC ACID Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1995-03-29 EP disclosed
CN-1023217-C Process for producing phenols MITSUI PETROCHEMICAL IND (JP) 1993-12-22 CN disclosed
CN-1033618-A Produce the method for phenol MITSUI PETROCHEMICAL IND (JP) 1989-07-05 CN disclosed