Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 13/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873619 | 0.92 | TP53 (0.34) | TP53THRBHCRTR1HCRTR2 | |
| SCHEMBL845092 | 0.91 | TP53 (0.41) | TP53THRBCFTR | |
| SCHEMBL874517 | 0.84 | THRB (0.36) | TP53THRBCFTR | |
| SCHEMBL845096 | 0.82 | TP53 (0.40) | TP53THRB | |
| SCHEMBL10119511 | 0.72 | GAA (0.44) | TP53 | |
| SCHEMBL845370 | 0.71 | PIK3CA (0.37) | THRBHCRTR1HCRTR2 | |
| SCHEMBL845518 | 0.65 | GAA (0.52) | TP53 | |
| SCHEMBL871645 | 0.60 | PABPC1 (0.43) | — | |
| SCHEMBL23260558 | 0.58 | CYP2C9 (0.43) | THRB | |
| SCHEMBL845312 | 0.58 | GAA (0.60) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |