Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736103 | 0.79 | CYSLTR1 (0.62) | CYSLTR1ALOX5 | |
| SCHEMBL8736505 | 0.77 | CYSLTR1 (0.53) | CYSLTR1 | |
| SCHEMBL28272270 | 0.76 | CYP1A2 (0.44) | — | |
| SCHEMBL9585620 | 0.71 | AKR1C3 (0.57) | CYSLTR1ALOX5APLTB4RALOX5PDE4A | |
| SCHEMBL9323970 | 0.71 | ALDH1A1 (0.39) | — | |
| SCHEMBL8734305 | 0.70 | CYSLTR1 (0.61) | CYSLTR1 | |
| SCHEMBL9703797 | 0.69 | PTGS2 (0.62) | — | |
| SCHEMBL9446975 | 0.69 | POLB (0.49) | ALOX5APLTB4R | |
| SCHEMBL8734300 | 0.68 | ALOX5 (0.59) | CYSLTR1ALOX5PDE4APDE4BPDE4C | |
| SCHEMBL9828316 | 0.68 | CYSLTR1 (0.54) | CYSLTR1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874826-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024331-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-07-10 | — | — | WO | disclosed |