Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 2/20 | 0.50 |
| ▸ | NOS2 | P35228 | 4/20 | 0.47 |
| ▸ | NOS3 | P29474 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29282154 | 0.72 | TSHR (0.43) | HTR5ANOS2NOS3TSHR | |
| SCHEMBL9949264 | 0.68 | HTR5A (0.51) | HTR5ANOS2NOS3TSHRHDAC8 | |
| SCHEMBL4666252 | 0.67 | TYMS (0.46) | HTR5ANOS2NOS3TYMSKDM4E | |
| SCHEMBL5684576 | 0.66 | PGR (0.47) | HTR5ANOS2NOS3TYMSNISCH | |
| SCHEMBL29517854 | 0.66 | PGR (0.47) | HTR5ANOS2NOS3TYMSNISCH | |
| SCHEMBL31703623 | 0.66 | TSHR (0.95) | HTR5ANOS2NOS3TSHRKDM4E | |
| SCHEMBL1194687 | 0.66 | TSHR (0.95) | HTR5ANOS2NOS3TSHRKDM4E | |
| Hydrochloric Acid SCHEMBL4092945 | 0.64 | TSHR (1.00) | HTR5ANOS2NOS3TSHRKDM4E | |
| Hydrochloric Acid SCHEMBL29386664 | 0.64 | TSHR (1.00) | HTR5ANOS2NOS3TSHRKDM4E | |
| SCHEMBL8487986 | 0.62 | NOS2 (0.52) | HTR5ANOS2NOS3TSHRTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640731-B9 | IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | LUNDBECK & CO AS H (DK) | 2015-11-25 | — | — | EP | disclosed |
| EP-2640731-B1 | IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | LUNDBECK & CO AS H (DK) | 2015-07-08 | — | — | EP | disclosed |
| US-9062060-B2 | Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-23 | — | — | US | disclosed |
| US-9062060-B2 | Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-23 | — | — | US | disclosed |
| US-20140357639-A1 | Imidazole derivatives as PDE10 enzyme inhibitors | H. LUNDBECK A/S (DK) | 2014-12-04 | — | — | US | disclosed |
| US-20140357639-A1 | Imidazole derivatives as PDE10 enzyme inhibitors | H. LUNDBECK A/S (DK) | 2014-12-04 | — | — | US | disclosed |
| US-8796304-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2014-08-05 | — | — | US | disclosed |
| US-8796304-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2014-08-05 | — | — | US | disclosed |
| US-8633210-B2 | Triazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-01-21 | — | — | US | disclosed |
| US-8552045-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2013-10-08 | — | — | US | disclosed |
| US-8552045-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2013-10-08 | — | — | US | disclosed |
| WO-2013045607-A1 | QUINAZOLINE LINKED HETEROAROMATIC TRICYCLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2013-04-04 | — | — | WO | disclosed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| US-20120129836-A1 | Imidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2012-05-24 | — | — | US | disclosed |
| US-20120129836-A1 | Imidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2012-05-24 | — | — | US | disclosed |
| WO-2012065612-A1 | IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2012-05-24 | — | — | WO | disclosed |
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
| US-7951820-B2 | Triazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129836-A1 | Imidazole derivatives as PDE10A enzyme inhibitors | PDE5A, PDE3A, PDE3B | HTR5A 96/4885NOS2 268/4885NOS3 395/4885 |
| US-20140357639-A1 | Imidazole derivatives as PDE10 enzyme inhibitors | PDE12, PDE5A, PDE10A | HTR5A 213/4885NOS2 158/4885NOS3 279/4885 |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | HTR5A 3335/4885NOS2 1695/4885NOS3 1625/4885 |
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | GSK3B, GSK3A, CDK19 | HTR5A 2788/4885NOS2 2918/4885NOS3 836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.