Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | GPR3 | P46089 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8733602 | 0.88 | PTGS2 (0.46) | PTGS2DRD1DRD2DRD4DRD5 | |
| SCHEMBL367003 | 0.87 | DRD2 (0.42) | MAPK1TDP1L3MBTL1PTGS2DRD1 | |
| Iodide SCHEMBL2865870 | 0.85 | STAT3 (0.46) | LMNAPTGS2SYKFFAR4ALDH1A1 | |
| Iodide SCHEMBL8735153 | 0.85 | PTGS2 (0.39) | PTGS2DRD1DRD2DRD4DRD5 | |
| Iodide SCHEMBL21220125 | 0.85 | PTGS2 (0.39) | MAPK1PTGS2DRD1DRD2DRD4 | |
| Iodide SCHEMBL8735177 | 0.85 | PTGS2 (0.44) | TDP1PTGS2DRD1DRD2DRD4 | |
| Hydrogen Sulfide SCHEMBL27520693 | 0.84 | PTGS2 (0.46) | TDP1L3MBTL1PTGS2DRD1DRD2 | |
| Hydrogen Sulfide SCHEMBL1088675 | 0.84 | DRD2 (0.43) | LMNAMAPK1TDP1L3MBTL1PTGS2 | |
| Iodide SCHEMBL8736570 | 0.84 | PTPN5 (0.41) | DRD2ALDH1A1 | |
| Hydrogen Sulfide SCHEMBL19066712 | 0.82 | STAT3 (0.46) | LMNAPTGS2SYKFFAR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697387-B1 | Improved method for the preparation of iodonium salts | DOW CORNING (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5426222-A | Mixing iodoarene dicarboxylate, solvent, adding acid to form homogeneous reaction mixture, reacting with benzene or substituted benzene, stripping solvent | DOW CORNING CORPORATION (US) | 1995-06-20 | — | — | US | disclosed |