Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 10/20 | 0.38 |
| ▸ | DRD2 | P14416 | 6/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD5 | P21918 | 3/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8733602 | 0.88 | PTGS2 (0.46) | PTGS2DRD1DRD2DRD3DRD4 | |
| SCHEMBL367003 | 0.87 | DRD2 (0.42) | PTGS2DRD1DRD2DRD3DRD4 | |
| Iodide SCHEMBL8735177 | 0.85 | PTGS2 (0.44) | PTGS2DRD1DRD2DRD3DRD4 | |
| Iodide SCHEMBL21220125 | 0.85 | PTGS2 (0.39) | PTGS2DRD1DRD2DRD3DRD4 | |
| Iodide SCHEMBL8737221 | 0.85 | LMNA (0.43) | PTGS2DRD1DRD2DRD3DRD4 | |
| Hydrogen Sulfide SCHEMBL27520693 | 0.84 | PTGS2 (0.46) | PTGS2DRD1DRD2DRD3DRD4 | |
| Iodide SCHEMBL2865870 | 0.82 | STAT3 (0.46) | PTGS2FFAR4ALDH1A1HPGD | |
| SCHEMBL7023211 | 0.82 | DRD2 (0.42) | DRD1DRD2DRD3DRD4DRD5 | |
| SCHEMBL28166225 | 0.81 | PTGS2 (0.41) | PTGS2DRD1DRD2DRD3DRD4 | |
| SCHEMBL16926997 | 0.80 | DRD2 (0.41) | DRD1DRD2DRD3DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697387-B1 | Improved method for the preparation of iodonium salts | DOW CORNING (US) | 1998-04-22 | — | — | EP | disclosed |