SCHEMBL367003

SCHEMBL367003

O=S(=O)(Oc1ccccc1-c1ccccc1)C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 5/20 0.42
PTGS2 P35354 2/20 0.41
DRD1 P21728 7/20 0.41
DRD3 P35462 3/20 0.41
DRD4 P21917 2/20 0.41
DRD5 P21918 2/20 0.41
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TP53 P04637 1/20 0.40
MAPK1 P28482 1/20 0.40
RAB9A P51151 1/20 0.40
NCOA1 Q15788 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
AR P10275 1/20 0.38
HTR1D P28221 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28166225 0.93 PTGS2 (0.41) DRD2PTGS2DRD1DRD3DRD4
SCHEMBL7023211 0.90 DRD2 (0.42) DRD2DRD1DRD3DRD4DRD5
Hydrogen Sulfide SCHEMBL27520693 0.90 PTGS2 (0.46) DRD2PTGS2DRD1DRD3DRD4
Iodide SCHEMBL8733602 0.90 PTGS2 (0.46) DRD2PTGS2DRD1DRD3DRD4
SCHEMBL16926997 0.89 DRD2 (0.41) DRD2DRD1DRD3DRD4DRD5
SCHEMBL28551762 0.89 PTPN1 (0.42) DRD2DRD1DRD3DRD4DRD5
SCHEMBL1423686 0.89 CYP11B1 (0.41) DRD2PTGS2DRD1DRD3DRD4
Iodide SCHEMBL8737221 0.87 LMNA (0.43) DRD2PTGS2DRD1DRD3DRD4
Iodide SCHEMBL21220125 0.87 PTGS2 (0.39) DRD2PTGS2DRD1DRD3DRD4
Iodide SCHEMBL8735153 0.87 PTGS2 (0.39) DRD2PTGS2DRD1DRD3DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1832922-A Sulfonyl-substituted N- (biarylmethyl) aminocyclopropanecarboxamides MERCK & CO INC (US) 2006-09-13 CN claimed
EP-4721534-A1 COMPOUND, ORGANIC LIGHT EMITTING DIODE, AND DISPLAY DEVICE Novaled GmbH (DE) 2026-04-08 EP disclosed
WO-2024246197-A1 COMPOUND, ORGANIC LIGHT EMITTING DIODE, AND DISPLAY DEVICE NOVALED GMBH (DE) 2024-12-05 WO disclosed
CN-118852159-A Heterogeneous palladium-catalyzed selective bell wood coupling reaction and application thereof in Wilmofini intermediate synthesis 哈尔滨工业大学(深圳)(哈尔滨工业大学深圳科技创新研究院) 2024-10-29 CN disclosed
CN-112469690-B Method for producing arylamines 默克专利有限公司 2024-04-16 CN disclosed
US-20240083926-A1 PHOSPHORUS COMPOUNDS AND METHODS THEREOF AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2024-03-14 US disclosed
CN-113527121-B C (sp3) -C (sp2) Bond construction method and preparation method of beta-aryl amino acid 河北科技大学 2023-01-17 CN disclosed
EP-3818038-B1 PROCESS FOR THE PRODUCTION OF ARYLAMINES MERCK PATENT GMBH (DE) 2022-08-03 EP disclosed
EP-4028381-A1 CANNABINOID DERIVATIVES, PRECURSORS AND USES Kare Chemical Technologies Inc. (CA) 2022-07-20 EP disclosed
WO-2022132048-A1 PHOSPHORUS COMPOUNDS AND METHODS THEREOF AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2022-06-23 WO disclosed
US-RE36256-E ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-07-20 US disclosed
US-5795889-A INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-08-18 US disclosed
EP-0813560-A2 SOLUBLE FLUORINATED POLY-P-PHENYLENES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-12-29 EP disclosed
US-5656643-A QUINOLIN PYRIDINE DERIVATIVES; USEFUL FOR TREATING CANCER, LEKEMIA, PSORIASIS, INFLAMMATORY DISODERS, BONE DISORDERS, ATHEROSCLEROSIS AND RESTENOSIS; CONTROLLS CELLULAR REPRODUCTION RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1997-08-12 US disclosed
US-5646153-A INHIBITING ABNORMAL CELL PROLIFERATION RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1997-07-08 US disclosed
WO-1996028491-A1 SOLUBLE FLUORINATED POLY-P-PHENYLENES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-09-19 WO disclosed
US-5530150-A HAVING PHOSPHINE AND PHOSPHITE GROUPS IN SAME MOLECULE; CATALYST SELECTIVITY TAKASAGO INTERNATIONAL CORPORATION (JP) 1996-06-25 US disclosed
US-5480883-A Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1996-01-02 US disclosed
US-5409930-A Inhibits abnoramal cell proliferation; dimethoxyquinoline/ dimethylquinoline/ quinolineoxide/ and quinoxaline derivatives RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1995-04-25 US disclosed
WO-1992020642-A1 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1992-11-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240083926-A1 PHOSPHORUS COMPOUNDS AND METHODS THEREOF PHPT1, PTH1R, SOST DRD2 3687/4885PTGS2 2114/4885DRD1 3158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.