SCHEMBL8739864

SCHEMBL8739864

Cc1ccc2c(c1)c1ccccc1n2-c1cccc(-c2cccc(-n3c4ccccc4c4ccccc43)c2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
ATM Q13315 1/20 0.48
GAA P10253 2/20 0.38
BCHE P06276 1/20 0.38
ACHE P22303 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
LMNA P02545 3/20 0.38
MAPT P10636 3/20 0.38
HTT P42858 2/20 0.38
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
NR1I2 O75469 1/20 0.38
AHR P35869 1/20 0.38
PGR P06401 1/20 0.38
RORA P35398 1/20 0.38
RORC P51449 1/20 0.38
RORB Q92753 1/20 0.38
ALDH1A1 P00352 3/20 0.36
FGFR1 P11362 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8739862 1.00 KDM4E (0.48) KDM4EL3MBTL1ATMGAABCHE
SCHEMBL8739859 1.00 KDM4E (0.48) KDM4EL3MBTL1ATMGAABCHE
SCHEMBL17166747 0.97 L3MBTL1 (0.46) KDM4EL3MBTL1ATMGAABCHE
SCHEMBL15458643 0.97 ATM (0.50) KDM4EL3MBTL1ATMGAABCHE
SCHEMBL30322587 0.95 KDM4E (0.44) KDM4EL3MBTL1ATMGAABCHE
SCHEMBL18180842 0.95 ATM (0.49) KDM4EL3MBTL1ATMGAABCHE
SCHEMBL18352232 0.95 KDM4E (0.44) KDM4EL3MBTL1ATMGAABCHE
SCHEMBL15435805 0.95 KDM4E (0.44) KDM4EL3MBTL1ATMGAABCHE
SCHEMBL30322780 0.95 KDM4E (0.44) KDM4EL3MBTL1ATMGAABCHE
SCHEMBL17178947 0.94 ATM (0.47) KDM4EL3MBTL1ATMGAABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160254462-A1 Material For Organic Electroluminescence Device And Organic Electroluminescence Device UDC IRELAND LTD (IE) 2016-09-01 US disclosed
US-9340728-B2 Organic electroluminescence device UDC IRELAND LIMITED (IE) 2016-05-17 US disclosed
US-9318714-B2 Material for organic electroluminescence device and organic electroluminescence device UDC Ireland (IE) 2016-04-19 US disclosed
US-9193747-B2 Organic electroluminescent device UDC IRELAND LIMITED (IE) 2015-11-24 US disclosed
US-8735878-B2 Charge transporting material and organic electroluminescence device UDC IRELAND LIMITED (IE) 2014-05-27 US disclosed
US-8679649-B2 Material for organic electroluminescence device, and organic electroluminescence device UDC IRELAND LIMITED (IE) 2014-03-25 US disclosed
US-20130270530-A1 ORGANIC ELECTROLUMINESCENT ELEMENT AND COMPOUND UDC IRELAND LIMITED (IE) 2013-10-17 US disclosed
US-20120256173-A1 CHARGE TRANSPORTING MATERIAL AND ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2012-10-11 US disclosed
US-20120169218-A1 MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE, AND ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2012-07-05 US disclosed
US-20120126690-A1 ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION 2012-05-24 US disclosed
US-20120126221-A1 CHARGE-TRANSPORTING MATERIAL AND ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2012-05-24 US disclosed
US-20110049497-A1 MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE FUJIFILM CORPORATION (JP) 2011-03-03 US disclosed
US-20100171111-A1 ORGANIC ELECTROLUMINESCENT DEVICE FUJIFILM CORPORATION (JP) 2010-07-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100171111-A1 ORGANIC ELECTROLUMINESCENT DEVICE NDUFS3, NDUFS2, NDUFS4 KDM4E 2299/4885L3MBTL1 963/4885ATM 3234/4885
US-20120126221-A1 CHARGE-TRANSPORTING MATERIAL AND ORGANIC ELECTROLUMINESCENCE DEVICE SLC26A3, SLC43A3, SLCO2A1 KDM4E 4092/4885L3MBTL1 1106/4885ATM 3592/4885
US-20160254462-A1 Material For Organic Electroluminescence Device And Organic Electroluminescence Device VCL, L1CAM, EML4 KDM4E 374/4885L3MBTL1 342/4885ATM 1530/4885
US-20120256173-A1 CHARGE TRANSPORTING MATERIAL AND ORGANIC ELECTROLUMINESCENCE DEVICE SLCO4C1, SLC39A3, SLC39A11 KDM4E 3988/4885L3MBTL1 570/4885ATM 4617/4885
US-20110049497-A1 MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE VCL, L1CAM, EML4 KDM4E 374/4885L3MBTL1 342/4885ATM 1530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.