Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744397 | 0.83 | GNAO1 (0.50) | ALOX15GNAI3GNAO1GNAI1 | |
| SCHEMBL8744361 | 0.81 | ALOX15 (0.38) | ALOX15GNAI3GNAO1GNAI1POLB | |
| SCHEMBL7475559 | 0.79 | KEAP1 (0.45) | ALOX15KEAP1SMN1; SMN2CHRM1GNAI3 | |
| SCHEMBL8744370 | 0.77 | NCF1 (0.35) | ALOX15 | |
| SCHEMBL2209216 | 0.75 | KEAP1 (0.45) | ALOX15KEAP1SMN1; SMN2GNAI3GNAO1 | |
| SCHEMBL12062280 | 0.73 | KEAP1 (0.38) | ALOX15KEAP1SMN1; SMN2CHRM1GNAI3 | |
| SCHEMBL8744432 | 0.72 | OPRM1 (0.33) | — | |
| SCHEMBL23078949 | 0.70 | ALOX15 (0.44) | ALOX15SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL1290862 | 0.69 | CARM1 (0.52) | KEAP1SMN1; SMN2POLBSIGMAR1 | |
| SCHEMBL8744341 | 0.69 | GNAO1 (0.57) | GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614534-A | Derivatives of β, β-dimethyl-4-piperidineethanamine as inhibitors of the cholesterol biosynthesis | FOURNIER INDUSTRIE ET SANTE (FR) | 1997-03-25 | — | — | US | disclosed |
| EP-0699187-B1 | BETA,BETA-DIMETHYL-4-PIPERIDINEETHANAMINE DERIVATIVES AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER IND & SANTE (FR) | 1997-01-22 | — | — | EP | disclosed |
| EP-0699187-A1 | DERIVATIVES OF -g(b), -g(b)-DIMETHYL-4-PIPERIDINEETHANAMINE AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER IND & SANTE (FR) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994026713-A1 | DERIVATIVES OF β, β-DIMETHYL-4-PIPERIDINEETHANAMINE AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER INDUSTRIE ET SANTE (FR) | 1994-11-24 | — | — | WO | disclosed |