SCHEMBL8744984

SCHEMBL8744984

Cc1ccccc1N1CCN(Cc2ccc(CC(=O)O)cc2)CC1

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.70
KDM4E B2RXH2 1/20 0.57
ALDH1A1 P00352 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
DRD2 P14416 2/20 0.54
DRD4 P21917 2/20 0.54
HTR7 P34969 1/20 0.53
LMNA P02545 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
ITGB3 P05106 2/20 0.52
ITGA2B P08514 2/20 0.52
ADRA1D P25100 1/20 0.52
ADRA1A P35348 1/20 0.52
ADRA1B P35368 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8745009 0.99 ATM (0.68) ATMKDM4EALDH1A1NPSR1DRD2
SCHEMBL8131885 0.85 ATM (0.67) ATMALDH1A1DRD2DRD4HTR7
SCHEMBL8744982 0.84 HTT (0.59) ATMALDH1A1DRD2DRD4LMNA
SCHEMBL8744970 0.84 CACNA1G (0.57) KDM4EALDH1A1DRD2DRD4LMNA
SCHEMBL8745020 0.84 ITGB3 (0.52) ATMALDH1A1NPSR1DRD2DRD4
SCHEMBL8744973 0.83 MAPK1 (0.70) KDM4EALDH1A1DRD2DRD4HTR7
SCHEMBL18177896 0.83 ATM (0.64) ATMKDM4EALDH1A1NPSR1DRD2
SCHEMBL6030752 0.83 LMNA (0.67) ATMKDM4EALDH1A1NPSR1DRD2
Hydrochloric Acid SCHEMBL8745014 0.83 CACNA1G (0.56) KDM4EALDH1A1DRD2DRD4LMNA
SCHEMBL8691440 0.81 DRD4 (0.70) ATMALDH1A1DRD2DRD4HTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0753515-A2 Benzylpiperazine derivatives as antiallergic and anti-inflammatory agents Senju Pharmaceutical Co., Ltd. (JP) 1997-01-15 EP claimed