Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8745816 | 0.94 | ADRA1A (0.55) | BRAFGAADRD2ADRA1AHTR2A | |
| SCHEMBL8745760 | 0.94 | ADRA1A (0.55) | BRAFGAADRD2ADRA1AHTR2A | |
| SCHEMBL9144743 | 0.93 | DRD2 (0.51) | BRAFDRD2ADRA1AHTR2AKCNH2 | |
| SCHEMBL8745769 | 0.92 | BRAF (0.55) | BRAFGAADRD2ADRA1AHTR2A | |
| SCHEMBL8745813 | 0.92 | BRAF (0.49) | BRAFGAADRD2ADRA1AHTR2A | |
| SCHEMBL8745809 | 0.89 | HTR2A (0.60) | BRAFDRD2ADRA1AHTR2AKCNH2 | |
| SCHEMBL8745759 | 0.89 | DRD2 (0.59) | BRAFDRD2HTR2AKCNH2DRD3 | |
| Ensaculin SCHEMBL29722503 | 0.84 | HTR2A (0.63) | DRD2ADRA1AHTR2AKCNH2HTR1A | |
| Ensaculin SCHEMBL677971 | 0.84 | HTR2A (0.63) | DRD2ADRA1AHTR2AKCNH2HTR1A | |
| SCHEMBL8745782 | 0.84 | DRD2 (0.54) | BRAFDRD2ADRA1AHTR2AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663911-B1 | BENZOPYRANONES, METHOD OF PREPARING THEM AND THEIR USE | SCHWABE WILLMAR GMBH & CO (DE) | 1997-02-05 | — | — | EP | disclosed |
| US-5550129-A | THERAPY FOR NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | WILLMAR SCHWABE GMBH & CO. (DE) | 1996-08-27 | — | — | US | disclosed |
| EP-0663911-A1 | BENZOPYRANONES, METHOD OF PREPARING THEM AND THEIR USE. | SCHWABE WILLMAR GMBH & CO (DE) | 1995-07-26 | — | — | EP | disclosed |
| WO-1994008985-A1 | BENZOPYRANONES, METHOD OF PREPARING THEM AND THEIR USE | DR. WILLMAR SCHWABE GMBH & CO. (DE) | 1994-04-28 | — | — | WO | disclosed |