Ensaculin

Ensaculin

SCHEMBL677971

COc1cc2oc(=O)c(C)c(C)c2cc1OCCCN1CCN(c2ccccc2OC)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.63
DRD2 P14416 2/20 0.63
ADRA1A P35348 2/20 0.63
KCNH2 Q12809 1/20 0.60
HTR1A P08908 2/20 0.57
HTR7 P34969 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ensaculin SCHEMBL29722503 1.00 HTR2A (0.63) HTR2ADRD2ADRA1AKCNH2HTR1A
SCHEMBL17343106 0.93 ALDH1A1 (0.58) HTR2ADRD2ADRA1AKCNH2HTR1A
SCHEMBL8805913 0.89 DRD2 (0.71) HTR2ADRD2ADRA1AHTR1A
SCHEMBL6739040 0.88 HTR7 (0.50) HTR2ADRD2ADRA1AKCNH2HTR7
SCHEMBL8810740 0.87 DRD2 (0.59) HTR2ADRD2ADRA1AKCNH2
Hydrochloric Acid SCHEMBL6952251 0.87 HTR7 (0.49) HTR2ADRD2ADRA1AHTR1AHTR7
Hydrochloric Acid SCHEMBL6740134 0.86 DRD2 (0.49) HTR2ADRD2ADRA1AHTR1AHTR7
SCHEMBL6735944 0.86 DRD2 (0.48) HTR2ADRD2ADRA1AKCNH2
SCHEMBL9144743 0.86 DRD2 (0.51) HTR2ADRD2ADRA1AKCNH2HTR1A
SCHEMBL6735246 0.85 DRD2 (0.47) HTR2ADRD2ADRA1AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091047-A1 THERAPEUTIC COMBINATIONS FOR MOVEMENT DISORDERS NATIVE CODE BIO LLC (US) 2026-04-02 US disclosed
EP-4665318-A2 THERAPEUTIC COMBINATIONS FOR INFLAMMATORY CONDITIONS AND DISORDERS Native Code Bio, LLC (US) 2025-12-24 EP disclosed
US-20250381149-A1 CATIONIC AMPHIPHILIC COMPOUND-BASED NANOPARTICLE COMPOSITIONS UNIVERSITEIT GENT (BE) 2025-12-18 US disclosed
EP-4583856-A2 THERAPEUTIC COMBINATIONS FOR MOVEMENT DISORDERS Native Code Bio, LLC (US) 2025-07-16 EP disclosed
EP-4547229-A1 CATIONIC AMPHIPHILIC COMPOUND-BASED NANOPARTICLE COMPOSITIONS Universiteit Gent (BE) 2025-05-07 EP disclosed
US-20250108082-A1 THERAPEUTIC COMBINATIONS FOR INFLAMMATORY CONDITIONS AND DISORDERS NATIVE CODE BIO, LLC 2025-04-03 US disclosed
WO-2024173954-A2 THERAPEUTIC COMBINATIONS FOR INFLAMMATORY CONDITIONS AND DISORDERS NATIVE CODE BIO, LLC (US) 2024-08-22 WO disclosed
US-20240142458-A1 FLUORESCENT PROBES FOR QUANTIFICATION OF FREE COPPER Technische Universität Berlin (DE) 2024-05-02 US disclosed
WO-2024054688-A2 THERAPEUTIC COMBINATIONS FOR MOVEMENT DISORDERS NATIVE CODE BIO, LLC (US) 2024-03-14 WO disclosed
WO-2024003363-A1 CATIONIC AMPHIPHILIC COMPOUND-BASED NANOPARTICLE COMPOSITIONS UNIVERSITEIT GENT (BE) 2024-01-04 WO disclosed
US-20070244143-A1 MODULATION OF NEUROGENESIS BY NOOTROPIC AGENTS BRAINCELLS, INC (US) 2007-10-18 US disclosed
WO-2007104035-A1 MODULATION OF NEUROGENESIS BY NOOTROPIC AGENTS BRAINCELLS, INC. (US) 2007-09-13 WO disclosed
US-20070208029-A1 MODULATION OF NEUROGENESIS BY PDE INHIBITION BRAINCELLS, INC. (US) 2007-09-06 US disclosed
US-20070112017-A1 GABA RECEPTOR MEDIATED MODULATION OF NEUROGENESIS BRAINCELLS, INC. (US) 2007-05-17 US disclosed
WO-2007053596-A1 GABA RECEPTOR MEDIATED MODULATION OF NEUROGENESIS BRAINCELLS, INC. (US) 2007-05-10 WO disclosed
WO-2007047978-A2 MODULATION OF NEUROGENESIS BY PDE INHIBITION BRAINCELLS, INC. (US) 2007-04-26 WO disclosed
US-20070078083-A1 MODULATION OF NEUORGENESIS BY HDac INHIBITION BRAINCELLS, INC. (US) 2007-04-05 US disclosed
WO-2007030697-A2 MODULATION OF NEUROGENESIS BY HDAC INHIBITION BRAINCELLS, INC. (US) 2007-03-15 WO disclosed
US-20070049576-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION BRAINCELLS, INC. (US) 2007-03-01 US disclosed
WO-2007025177-A2 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION BRAINCELLS, INC. (US) 2007-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070112017-A1 GABA RECEPTOR MEDIATED MODULATION OF NEUROGENESIS GABRB2, GAP43, GABRB1 HTR2A 524/4885DRD2 1115/4885ADRA1A 984/4885
US-20250108082-A1 THERAPEUTIC COMBINATIONS FOR INFLAMMATORY CONDITIONS AND DISORDERS HMBS, P2RY13, FDPS HTR2A 3151/4885DRD2 4096/4885ADRA1A 3887/4885
US-20070078083-A1 MODULATION OF NEUORGENESIS BY HDac INHIBITION DCX, BDNF, NTRK2 HTR2A 3184/4885DRD2 4305/4885ADRA1A 3896/4885
US-20260091047-A1 THERAPEUTIC COMBINATIONS FOR MOVEMENT DISORDERS HMBS, SNCA, PYGB HTR2A 269/4885DRD2 297/4885ADRA1A 1947/4885
US-20070208029-A1 MODULATION OF NEUROGENESIS BY PDE INHIBITION PDE2A, PDE4A, DCX HTR2A 1221/4885DRD2 2243/4885ADRA1A 1309/4885
US-20250381149-A1 CATIONIC AMPHIPHILIC COMPOUND-BASED NANOPARTICLE COMPOSITIONS NPC1L1, NPC1, ABCB4 HTR2A 4186/4885DRD2 4816/4885ADRA1A 2109/4885
US-20070244143-A1 MODULATION OF NEUROGENESIS BY NOOTROPIC AGENTS GAP43, BDNF, DCX HTR2A 273/4885DRD2 647/4885ADRA1A 1011/4885
US-20070049576-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION CHRNB2, CHAT, CHRNB4 HTR2A 406/4885DRD2 1528/4885ADRA1A 458/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.