Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8745798 | 0.92 | BRAF (0.56) | BRAFDRD2ADRA1ADRD3HTR2A | |
| SCHEMBL8745816 | 0.87 | ADRA1A (0.55) | BRAFDRD2ADRA1ADRD3HTR2A | |
| SCHEMBL8745760 | 0.86 | ADRA1A (0.55) | BRAFDRD2ADRA1AHTR2AGAA | |
| SCHEMBL8745809 | 0.86 | HTR2A (0.60) | BRAFDRD2ADRA1ADRD3HTR2A | |
| SCHEMBL9144743 | 0.86 | DRD2 (0.51) | BRAFDRD2ADRA1ADRD3HTR2A | |
| SCHEMBL8745813 | 0.85 | BRAF (0.49) | BRAFDRD2ADRA1ADRD3HTR2A | |
| SCHEMBL8745817 | 0.84 | CCR4 (0.54) | BRAFDRD2ADRA1ADRD3GAA | |
| SCHEMBL8745759 | 0.82 | DRD2 (0.59) | BRAFDRD2DRD3HTR2AKCNH2 | |
| SCHEMBL8745788 | 0.80 | ABCC1 (0.56) | BRAFDRD2ADRA1AHTR2AGAA | |
| SCHEMBL8745797 | 0.79 | ALDH1A1 (0.56) | DRD2ADRA1ADRD3HTR2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663911-B1 | BENZOPYRANONES, METHOD OF PREPARING THEM AND THEIR USE | SCHWABE WILLMAR GMBH & CO (DE) | 1997-02-05 | — | — | EP | disclosed |
| US-5550129-A | THERAPY FOR NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | WILLMAR SCHWABE GMBH & CO. (DE) | 1996-08-27 | — | — | US | disclosed |
| EP-0663911-A1 | BENZOPYRANONES, METHOD OF PREPARING THEM AND THEIR USE. | SCHWABE WILLMAR GMBH & CO (DE) | 1995-07-26 | — | — | EP | disclosed |
| WO-1994008985-A1 | BENZOPYRANONES, METHOD OF PREPARING THEM AND THEIR USE | DR. WILLMAR SCHWABE GMBH & CO. (DE) | 1994-04-28 | — | — | WO | disclosed |