Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 13/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874398 | 0.90 | NAMPT (0.50) | NAMPTHDAC1PPARAPPARGPPARD | |
| SCHEMBL10069647 | 0.87 | NAMPT (0.47) | NAMPTHDAC1PPARAPPARGPPARD | |
| SCHEMBL10069703 | 0.80 | NAMPT (0.45) | NAMPTHDAC1PPARAPPARGPPARD | |
| SCHEMBL875591 | 0.80 | NAMPT (0.46) | NAMPTHDAC1PPARA | |
| SCHEMBL874752 | 0.80 | NAMPT (0.52) | NAMPTHDAC1PPARAPPARGPPARD | |
| SCHEMBL875947 | 0.75 | PPARA (0.49) | NAMPTHDAC1PPARAPPARGPPARD | |
| SCHEMBL873941 | 0.74 | RAB9A (0.48) | PPARAPPARGPPARD | |
| SCHEMBL15030902 | 0.73 | NPC1 (0.68) | NAMPTHDAC1 | |
| SCHEMBL875487 | 0.73 | HDAC1 (0.45) | NAMPTHDAC1PPARAMTOR | |
| SCHEMBL874757 | 0.72 | HDAC1 (0.44) | NAMPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |