Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 | Q09470 | 6/20 | 0.46 |
| ▸ | KCNAB1 | Q14722 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993384 | 0.84 | KCNA1 (0.51) | KCNA1KCNAB1KMT2AMEN1PTPN11 | |
| SCHEMBL8879442 | 0.76 | KCNA1 (0.58) | KCNA1KCNAB1PTPN11MAPTRAB9A | |
| SCHEMBL8879166 | 0.75 | KCNA1 (0.56) | KCNA1KCNAB1KMT2AMEN1MAPT | |
| SCHEMBL8761266 | 0.74 | PKM (0.60) | KCNA1KCNAB1KMT2AMEN1MAPT | |
| Ly-295501 SCHEMBL29375534 | 0.72 | PKM (0.58) | KCNA1KCNAB1KMT2AMEN1MAPT | |
| Ly-295501 SCHEMBL30351 | 0.72 | PKM (0.58) | KCNA1KCNAB1KMT2AMEN1MAPT | |
| SCHEMBL8761148 | 0.72 | PKM (0.51) | KCNA1KCNAB1KMT2AMEN1MAPT | |
| SCHEMBL9487998 | 0.71 | KMT2A (0.76) | KCNA1KCNAB1KMT2AMEN1MAPT | |
| SCHEMBL9529462 | 0.71 | EPHX1 (0.60) | KMT2AMEN1GAAGFERMAPT | |
| SCHEMBL9487105 | 0.71 | MEN1 (0.62) | KCNA1KCNAB1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614887-B1 | Indole-sulfonamides as antitumor agents | LILLY CO ELI (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0614887-A1 | Indole-sulfonamides as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-09-14 | — | — | EP | disclosed |