Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 3/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878507 | 0.95 | CCR5 (0.35) | POLBJAK2JAK1CCR5F10 | |
| SCHEMBL875757 | 0.89 | CCR5 (0.35) | POLBJAK2JAK1CCR5F10 | |
| SCHEMBL876171 | 0.86 | ALDH1A1 (0.36) | POLBJAK2JAK1CCR5F10 | |
| SCHEMBL876267 | 0.85 | F10 (0.36) | POLBJAK2JAK1CCR5F10 | |
| SCHEMBL876498 | 0.79 | SLC2A1 (0.38) | POLBJAK2JAK1CCR5F10 | |
| SCHEMBL784878 | 0.79 | ACHE (0.43) | POLBJAK2JAK1CCR5F10 | |
| SCHEMBL876131 | 0.78 | POLB (0.34) | POLBJAK2JAK1CCR5F10 | |
| SCHEMBL876499 | 0.77 | SLC2A1 (0.35) | POLBJAK2JAK1CCR5F10 | |
| SCHEMBL876714 | 0.77 | CCR5 (0.38) | POLBJAK2JAK1CCR5F10 | |
| SCHEMBL878283 | 0.76 | BDKRB1 (0.40) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | claimed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | claimed |
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |