Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8761334 | 0.89 | SMN1; SMN2 (0.40) | MAPK1LMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL8762413 | 0.78 | MAPK1 (0.45) | MAPK1LMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL8625810 | 0.77 | POLB (0.44) | MAPTALDH1A1CYP3A4RAB9APOLB | |
| SCHEMBL8762407 | 0.76 | L3MBTL1 (0.49) | MAPK1LMNAALDH1A1RAB9AHTT | |
| SCHEMBL8627352 | 0.75 | EPHX1 (0.34) | — | |
| SCHEMBL8763079 | 0.74 | ECE1 (0.30) | — | |
| SCHEMBL3614049 | 0.70 | NAMPT (0.56) | MAPK1LMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL2141942 | 0.70 | ALDH1A1 (0.52) | MAPK1LMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL28170723 | 0.69 | RAB9A (0.56) | MAPK1LMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL1709279 | 0.68 | RAB9A (0.63) | MAPK1LMNAMAPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636141-B1 | PYRIMIDINYL ACETAMIDES AS ELASTASE INHIBITORS | ZENECA LTD (GB) | 1997-06-25 | — | — | EP | disclosed |