Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ALPG | P10696 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166050 | 0.84 | HDAC4 (0.41) | LMNASMN1; SMN2ALDH1A1HPGDHTT | |
| SCHEMBL6097343 | 0.84 | TSHR (0.44) | LMNASMN1; SMN2ALDH1A1ALPGHPGD | |
| SCHEMBL11809770 | 0.81 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1ALPGHPGD | |
| SCHEMBL10978426 | 0.79 | LMNA (0.53) | LMNASMN1; SMN2ALDH1A1ALPGHPGD | |
| SCHEMBL21383218 | 0.78 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1ALPGHPGD | |
| SCHEMBL1720514 | 0.78 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1ALPGHPGD | |
| SCHEMBL9171467 | 0.78 | MAOA (0.41) | LMNASMN1; SMN2ALDH1A1ALPGHPGD | |
| SCHEMBL1008191 | 0.78 | MDM2 (0.40) | LMNAHTT | |
| SCHEMBL20767316 | 0.77 | SLC6A3 (0.41) | LMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL17355093 | 0.75 | ALDH1A1 (0.49) | LMNASMN1; SMN2ALDH1A1ALPGHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022200-B1 | NEW ANTI-MALARIAL AGENTS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2017-03-01 | — | — | EP | disclosed |
| EP-3022200-B1 | NEW ANTI-MALARIAL AGENTS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2017-03-01 | — | — | EP | disclosed |
| US-9464057-B2 | Anti-malarial agents | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2016-10-11 | — | — | US | disclosed |
| US-9464057-B2 | Anti-malarial agents | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2016-10-11 | — | — | US | disclosed |
| US-9464057-B2 | Anti-malarial agents | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2016-10-11 | — | — | US | disclosed |
| US-20160194286-A1 | NEW ANTI-MALARIAL AGENTS | UNIVERSITY OF WASHINGTON | 2016-07-07 | — | — | US | disclosed |
| US-20160194286-A1 | NEW ANTI-MALARIAL AGENTS | UNIVERSITY OF WASHINGTON | 2016-07-07 | — | — | US | disclosed |
| US-20160194286-A1 | NEW ANTI-MALARIAL AGENTS | UNIVERSITY OF WASHINGTON | 2016-07-07 | — | — | US | disclosed |
| EP-3022200-A1 | NEW ANTI-MALARIAL AGENTS | MMV Medicines for Malaria Venture (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015008246-A1 | NEW ANTI-MALARIAL AGENTS | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2015-01-22 | — | — | WO | disclosed |
| WO-2015008246-A1 | NEW ANTI-MALARIAL AGENTS | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2015-01-22 | — | — | WO | disclosed |
| EP-0375670-B1 | Process for preparing 3-polyfluoroalkylisoxazolylamines | SHIONOGI & CO (JP) | 1997-08-06 | — | — | EP | disclosed |
| EP-0220947-B1 | Polyfluoroalkylisoxazolylamines, their preparation and use | SHIONOGI & CO (JP) | 1994-06-15 | — | — | EP | disclosed |
| EP-0375670-A2 | Process for preparing 3-polyfluoroalkylisoxazolylamines | SHIONOGI & CO., LTD. (JP) | 1990-06-27 | — | — | EP | disclosed |
| US-4797492-A | INTERMEDIATES FOR BACTERICIDES; HERBICIDES OR FUNGICIDES | SHIONOGI & CO., LTD. (JP) | 1989-01-10 | — | — | US | disclosed |
| EP-0220947-A2 | Polyfluoroalkylisoxazolylamines, their preparation and use | SHIONOGI & CO., LTD. (JP) | 1987-05-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194286-A1 | NEW ANTI-MALARIAL AGENTS | CYP51A1, QDPR, G6PD | LMNA 3995/4885SMN1; SMN2 4313/4885ALDH1A1 1099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.