Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.46 |
| ▸ | PPARA | Q07869 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 3/20 | 0.45 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8925673 | 0.91 | HDAC1 (0.44) | PPARGPPARAHDAC1HDAC6HDAC3 | |
| SCHEMBL8768874 | 0.84 | PPARG (0.46) | PPARGPPARAHDAC1HDAC6HDAC3 | |
| SCHEMBL8768938 | 0.80 | PPARA (0.54) | PPARGPPARAHDAC1HDAC6HDAC3 | |
| SCHEMBL8768759 | 0.79 | PPARA (0.53) | PPARGPPARAHDAC1HDAC6HDAC3 | |
| SCHEMBL8925558 | 0.75 | PPARA (0.40) | PPARGPPARAHDAC1HDAC6HDAC3 | |
| SCHEMBL8767768 | 0.74 | PPARA (0.56) | PPARGPPARAPPARDSOAT1 | |
| SCHEMBL8767912 | 0.74 | SOAT1 (0.48) | PPARGPPARAHDAC1HDAC6HDAC3 | |
| SCHEMBL8925426 | 0.72 | PPARA (0.45) | PPARGPPARAHDAC1HDAC6HDAC3 | |
| SCHEMBL8768899 | 0.71 | PPARA (0.57) | PPARGPPARAHDAC1HDAC6HDAC3 | |
| SCHEMBL8924425 | 0.71 | PPARA (0.44) | PPARGPPARAHDAC1HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639178-B1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | WELLCOME FOUND (GB) | 1997-09-03 | — | — | EP | disclosed |