Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103313 | 0.93 | LMNA (0.45) | LMNATSHRSMN1; SMN2HTTKMT2A | |
| SCHEMBL8767453 | 0.89 | LMNA (0.42) | LMNATSHRSMN1; SMN2HTTKMT2A | |
| SCHEMBL8874073 | 0.88 | LMNA (0.47) | LMNATSHRSMN1; SMN2HTTKMT2A | |
| SCHEMBL8873584 | 0.86 | LMNA (0.47) | LMNATSHRSMN1; SMN2HTTKMT2A | |
| SCHEMBL8767110 | 0.86 | LMNA (0.40) | LMNATSHRSMN1; SMN2HTTKMT2A | |
| SCHEMBL8097853 | 0.83 | LMNA (0.49) | LMNATSHRSMN1; SMN2HTTKMT2A | |
| SCHEMBL8917593 | 0.83 | L3MBTL1 (0.43) | LMNATSHRSMN1; SMN2HTTKMT2A | |
| SCHEMBL9018193 | 0.81 | LMNA (0.53) | LMNATSHRSMN1; SMN2HTTKMT2A | |
| SCHEMBL8875248 | 0.80 | LMNA (0.41) | LMNATSHRSMN1; SMN2HTTKMT2A | |
| SCHEMBL8768360 | 0.80 | L3MBTL1 (0.50) | LMNATSHRSMN1; SMN2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673931-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 1997-08-13 | — | — | EP | disclosed |
| EP-0673931-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |