Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768360 | 0.89 | L3MBTL1 (0.50) | LMNAKMT2AALDH1A1TSHRHPGD | |
| SCHEMBL8103313 | 0.89 | LMNA (0.45) | LMNAKMT2AALDH1A1TSHRHPGD | |
| SCHEMBL8786669 | 0.87 | HPGDS (0.56) | KMT2AALDH1A1TSHRHPGDHPGDS | |
| SCHEMBL8097851 | 0.87 | LMNA (0.51) | LMNAKMT2AALDH1A1TSHRHPGD | |
| SCHEMBL8768279 | 0.84 | LMNA (0.42) | LMNAKMT2AALDH1A1TSHRHPGD | |
| SCHEMBL8768228 | 0.83 | LMNA (0.45) | LMNAKMT2AALDH1A1TSHRHPGD | |
| SCHEMBL8767487 | 0.83 | PTGS2 (0.55) | TDP1GAA | |
| SCHEMBL8103050 | 0.83 | LMNA (0.44) | LMNAKMT2AALDH1A1TSHRHPGD | |
| SCHEMBL8916898 | 0.82 | L3MBTL1 (0.52) | LMNAKMT2AALDH1A1TSHRHPGD | |
| Hydrochloric Acid SCHEMBL9231980 | 0.82 | PTGS2 (0.54) | TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673932-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides as well as their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 2000-06-07 | — | — | EP | disclosed |
| EP-0673931-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |