SCHEMBL8768261

SCHEMBL8768261

COc1ccc(S(=O)(=O)NC(=O)c2ccc(NC(=O)NSc3ccc4ccccc4c3)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.54
RAB9A P51151 4/20 0.53
NPC1 O15118 3/20 0.53
CASP3 P42574 1/20 0.53
SENP7 Q9BQF6 1/20 0.53
LMNA P02545 1/20 0.48
BCL2 P10415 1/20 0.48
BCL2L1 Q07817 1/20 0.48
MCL1 Q07820 1/20 0.48
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
RAPGEF3 O95398 1/20 0.46
GPR27 Q9NS67 1/20 0.46
ENPP1 P22413 1/20 0.45
MMP2 P08253 1/20 0.45
MMP9 P14780 1/20 0.45
ENPP2 Q13822 1/20 0.45
POLB P06746 1/20 0.44
CTDSP1 Q9GZU7 1/20 0.44
PTGER3 P43115 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8767632 0.90 LMNA (0.51) RAB9ANPC1LMNAKMT2AMEN1
SCHEMBL7776157 0.90 HSD17B10 (0.58) HSD17B10RAB9ANPC1LMNABCL2
SCHEMBL8768272 0.90 GPR27 (0.51) RAB9ANPC1LMNABCL2L1MCL1
SCHEMBL8768060 0.89 KAT6A (0.51) LMNABCL2L1MCL1KMT2AMEN1
SCHEMBL8768073 0.88 NPC1 (0.66) HSD17B10RAB9ANPC1CASP3SENP7
SCHEMBL7770073 0.87 HSD17B10 (0.57) HSD17B10RAB9ANPC1LMNAKMT2A
SCHEMBL8767411 0.85 FLT1 (0.51) RAB9ANPC1BCL2BCL2L1MCL1
SCHEMBL8659346 0.82 HSD17B10 (0.67) HSD17B10RAB9ANPC1LMNABCL2L1
SCHEMBL7774810 0.82 HSD17B10 (0.67) HSD17B10RAB9ANPC1LMNABCL2L1
SCHEMBL8767375 0.81 CA2 (0.42) RAB9ANPC1CASP3SENP7LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788889-A2 A thermal sensitive recording sheet NIPPON PAPER INDUSTRIES CO., LTD. (JP) 1997-08-13 EP disclosed