SCHEMBL8768956

SCHEMBL8768956

CCN(c1ccc(OC)cc1)c1c(Nc2ccc(C#N)cc2)c(=O)c1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 2/20 0.46
GSK3B P49841 1/20 0.41
KCNA5 P22460 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
KDR P35968 2/20 0.39
HDAC3 O15379 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
SIRT2 Q8IXJ6 2/20 0.38
MAPT P10636 4/20 0.38
LMNA P02545 2/20 0.38
ACP1 P24666 1/20 0.37
SMN1; SMN2 Q16637 4/20 0.36
KDM4E B2RXH2 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8768608 0.87 RORC (0.40) ADAMTS5GSK3BKCNA5HDAC1ALDH1A1
SCHEMBL8768875 0.86 CXCR2 (0.43) ADAMTS5MAPTNPSR1
SCHEMBL8767671 0.82 CXCR2 (0.45) ADAMTS5MEN1KMT2AMAPTLMNA
SCHEMBL8768638 0.77 ADAMTS5 (0.44) ADAMTS5KCNA5KMT2A
SCHEMBL8768958 0.73 KDR (0.52) GSK3BMEN1KMT2AKDRHDAC3
SCHEMBL5450744 0.72 GAA (0.68) GSK3BMEN1KMT2AKDRMAPT
SCHEMBL8769026 0.71 ADAMTS5 (0.46) ADAMTS5MEN1KMT2AHDAC1MAPT
SCHEMBL8872684 0.71 MAPKAPK2 (0.48) GSK3BMEN1KMT2AHDAC3HDAC1
SCHEMBL8872677 0.71 MAPKAPK2 (0.48) GSK3BMEN1KMT2AHDAC3HDAC1
SCHEMBL2771229 0.70 CXCR2 (0.43) GSK3BMEN1KMT2AKDRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP claimed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO claimed