SCHEMBL8770163

SCHEMBL8770163

C=CC(C)Cc1ccccc1[SiH3]

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.31
GABRB2 P47870 1/20 0.31
ADRB2 P07550 3/20 0.31
ADRB1 P08588 3/20 0.31
LMNA P02545 2/20 0.31
HTR1A P08908 1/20 0.31
ADRB3 P13945 1/20 0.31
ADRA2C P18825 1/20 0.31
SLC6A2 P23975 1/20 0.31
BDKRB2 P30411 1/20 0.31
SLC6A4 P31645 1/20 0.31
ADRA1A P35348 1/20 0.31
HTR2B P41595 1/20 0.31
KCNH2 Q12809 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
TSHR P16473 1/20 0.31
NFKB1 P19838 1/20 0.31
KDM4E B2RXH2 1/20 0.30
PMP22 Q01453 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8848613 0.78 TAAR1 (0.41) SLC6A2SLC6A4KCNH2CYP2D6TSHR
SCHEMBL8769551 0.78 ADRB2 (0.35) ADRB2ADRB1LMNAHTR1AADRB3
SCHEMBL3669290 0.77 ALDH1A1 (0.38) GABRA1GABRB2ADRB2ADRB1LMNA
SCHEMBL248875 0.77 SLC6A2 (0.46) LMNASLC6A2SLC6A4
SCHEMBL10319687 0.74 GABRA1 (0.34) GABRA1GABRB2ADRB1LMNAHTR1A
SCHEMBL8512691 0.72 TRPA1 (0.33) GABRA1GABRB2LMNASLC6A2SLC6A4
SCHEMBL8846364 0.71 TAAR1 (0.52) ADRA2CSLC6A2SLC6A4ADRA1AKCNH2
SCHEMBL2478602 0.69 GABRA1 (0.47) GABRA1GABRB2ADRB2ADRB1LMNA
SCHEMBL2103830 0.69 PNMT (0.30)
SCHEMBL25011137 0.68 GRIN2D (0.51) LMNASLC6A4CYP1A2CYP2D6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0604401-B1 Production of a catalyst component for producing crystalline polymers CHISSO CORP (JP) 1997-09-24 EP disclosed
EP-0395391-B1 Catalyst component for producing crystalline polymers and a process for producing the catalyst CHISSO CORP (JP) 1996-09-25 EP disclosed
EP-0564004-B1 A highly stereoregular polypropylene CHISSO CORP (JP) 1996-09-25 EP disclosed
EP-0404519-B1 A process for producing a high-stiffness polypropylene CHISSO CORP (JP) 1996-08-07 EP disclosed
EP-0604401-A2 Production of a catalyst component for producing crystalline polymers CHISSO CORPORATION (JP) 1994-06-29 EP disclosed
EP-0564004-A1 A highly stereoregular polypropylene CHISSO CORPORATION (JP) 1993-10-06 EP disclosed
US-5173540-A Coordination catalyst comprising titanium compound, organo aluminum compound electron donor and a polymer support; transparent, voidless films produced CHISSO CORPORATION (JP) 1992-12-22 US disclosed
US-5077341-A Using coordination catalyst CHISSO CORPORATION (JP) 1991-12-31 US disclosed
EP-0404519-A2 A process for producing a high-stiffness polypropylene CHISSO CORPORATION (JP) 1990-12-27 EP disclosed
EP-0395391-A2 Catalyst component for producing crystalline polymers and a process for producing the catalyst CHISSO CORPORATION (JP) 1990-10-31 EP disclosed