Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696392 | 0.73 | CA2 (0.41) | PTGS2PTGS1PTGES2 | |
| SCHEMBL1069769 | 0.71 | PTGES2 (0.42) | PTGS2PTGS1PTGES2 | |
| SCHEMBL28469382 | 0.70 | PTGES2 (0.51) | PTGS2PTGS1PTGES2 | |
| SCHEMBL2568289 | 0.70 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL29135575 | 0.69 | IKBKB (0.43) | PTGES2IKBKBCHUKMAOB | |
| Hydrochloric Acid SCHEMBL5794623 | 0.69 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL8662997 | 0.69 | PTGES2 (0.51) | PTGES2 | |
| SCHEMBL8661463 | 0.68 | PTGES2 (0.39) | PTGES2 | |
| SCHEMBL28022377 | 0.68 | CA2 (0.40) | PTGS2PTGS1PTGES2MAOB | |
| SCHEMBL31457601 | 0.68 | PGAM1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794942-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016934-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-06-06 | — | — | WO | disclosed |