SCHEMBL8770822

SCHEMBL8770822

O=P(O)(O)Oc1cc2ccccc2cc1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
INPPL1 O15357 12/20 0.50
INPP5A Q14642 6/20 0.50
SRC P12931 3/20 0.50
INPP5B P32019 2/20 0.50
GPR84 Q9NQS5 1/20 0.49
KDM4E B2RXH2 1/20 0.46
USP2 O75604 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46
PDE3A Q14432 1/20 0.46
HSD17B10 Q99714 1/20 0.46
AKT1 P31749 1/20 0.45
MEN1 O00255 1/20 0.41
MITF O75030 1/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41
NCOA1 Q15788 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
NCOA3 Q9Y6Q9 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20816425 0.81 INPPL1 (0.42) INPPL1INPP5ASRCINPP5BKDM4E
SCHEMBL8389196 0.81 INPPL1 (0.67) INPPL1INPP5ASRCINPP5BKDM4E
SCHEMBL28295682 0.76 GPR84 (0.67) INPPL1INPP5ASRCINPP5BGPR84
SCHEMBL29655758 0.75 INPPL1 (0.59) INPPL1INPP5ASRCINPP5BKDM4E
SCHEMBL522291 0.75 INPPL1 (0.59) INPPL1INPP5ASRCINPP5BKDM4E
SCHEMBL3791045 0.74 INPPL1 (0.53) INPPL1INPP5ASRCINPP5BGPR84
SCHEMBL8415403 0.74 INPPL1 (0.42) INPPL1INPP5AINPP5BGPR84KDM4E
SCHEMBL2573126 0.74 INPPL1 (0.70) INPPL1INPP5ASRCINPP5BKDM4E
SCHEMBL28895404 0.74 INPPL1 (0.57) INPPL1INPP5ASRCINPP5BKDM4E
Ammonia Solution, Strong SCHEMBL11748950 0.74 INPPL1 (0.57) INPPL1INPP5ASRCINPP5BKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10443084-B2 Naphthalene derived chromogenic enzyme substrates GLYCOSYNTH LIMITED (GB) 2019-10-15 US disclosed
US-9938562-B2 Naphthalene derived chromogenic enzyme substrates GLYCOSYNTH LIMITED (GB) 2018-04-10 US disclosed
US-9938562-B2 Naphthalene derived chromogenic enzyme substrates GLYCOSYNTH LIMITED (GB) 2018-04-10 US disclosed
EP-3066209-B1 NAPHTHALENE DERIVED CHROMOGENIC ENZYME SUBSTRATES GLYCOSYNTH LTD (GB) 2017-12-06 EP disclosed
US-20160298167-A1 NAPHTHALENE DERIVED CHROMOGENIC ENZYME SUBSTRATES GLYCOSYNTH LIMITED (GB) 2016-10-13 US disclosed
US-20160298167-A1 NAPHTHALENE DERIVED CHROMOGENIC ENZYME SUBSTRATES GLYCOSYNTH LIMITED (GB) 2016-10-13 US disclosed
WO-2015067927-A1 NAPHTHALENE DERIVED CHROMOGENIC ENZYME SUBSTRATES GLYCOSYNTH LIMITED (GB) 2015-05-14 WO disclosed
EP-0629395-B1 Keratinous fiber treatment compositions KAO CORP (JP) 1997-10-01 EP disclosed
EP-0629395-A1 Keratinous fiber treatment compositions Kao Corporation (JP) 1994-12-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10443084-B2 Naphthalene derived chromogenic enzyme substrates MGAM, UGDH, ME1 INPPL1 2525/4885INPP5A 2742/4885SRC 4243/4885
US-20160298167-A1 NAPHTHALENE DERIVED CHROMOGENIC ENZYME SUBSTRATES CYP2R1, TDO2, XDH INPPL1 3373/4885INPP5A 3482/4885SRC 4223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.