Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642701 | 0.82 | KMT2A (0.40) | HSD17B10KMT2AHTTTSHRSMN1; SMN2 | |
| SCHEMBL18680750 | 0.79 | RAPGEF4 (0.35) | KMT2ARAPGEF4MAPTALDH1A1MEN1 | |
| SCHEMBL645965 | 0.78 | ALDH1A1 (0.38) | HSD17B10TSHRHPGDKDM4EMAPT | |
| SCHEMBL1145370 | 0.78 | AHR (0.43) | HSD17B10KMT2AHTTTSHRHPGD | |
| SCHEMBL15315300 | 0.77 | MCL1 (0.34) | HSD17B10TSHRHPGDKDM4EMAPT | |
| SCHEMBL28247948 | 0.77 | SLC6A3 (0.36) | KMT2ATSHRRAPGEF4MAPTMEN1 | |
| SCHEMBL6886003 | 0.74 | HSD17B10 (0.41) | HSD17B10KMT2AHTTTSHRHPGD | |
| SCHEMBL12410552 | 0.74 | MCL1 (0.35) | HSD17B10TSHRHPGDKDM4EMAPT | |
| SCHEMBL4417489 | 0.74 | MAPT (0.40) | HSD17B10KMT2ATSHRHPGDKDM4E | |
| SCHEMBL3789458 | 0.74 | KMT2A (0.41) | HSD17B10KMT2AHTTTSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067657-A1 | AMIDO-SUBSTITUTED PYRIDYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES | MERCK SHARP & DOHME LLC (US) | 2024-02-29 | — | — | US | disclosed |
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | LOXO ONCOLOGY, INC. | 2024-01-18 | — | — | US | disclosed |
| WO-2020150674-A1 | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS | NUVATION BIO INC. (US) | 2020-07-23 | — | — | WO | disclosed |
| US-10000522-B2 | Derivatives of uridine 5′-cyclophosphate useful to treat hepatitis C viral infections | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2018-06-19 | — | — | US | disclosed |
| US-20170334942-A1 | DERIVATIVES OF URIDINE 5'-CYCLOPHOSPHATE USEFUL TO TREAT HEPATITIS C VIRAL INFECTIONS | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2017-11-23 | — | — | US | disclosed |
| EP-2826826-A1 | Composition for forming a coating type BPSG film, substrate formed a film by said composition, and patterning process using said composition | Shin-Etsu Chemical Co., Ltd. (JP) | 2015-01-21 | — | — | EP | disclosed |
| WO-2012069652-A2 | FUNGICIDE MIXTURES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-31 | — | — | WO | disclosed |
| US-20120129875-A1 | SUBSTITUTED QUINAZOLINES AS FUNGICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120129875-A1 | SUBSTITUTED QUINAZOLINES AS FUNGICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-05-24 | — | — | US | disclosed |
| WO-2010136475-A1 | SUBSTITUTED QUINAZOLINES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PIK3CA, PIK3R4, PIK3R5 | HSD17B10 450/4885KMT2A 4426/4885HTT 1751/4885 |
| US-10000522-B2 | Derivatives of uridine 5′-cyclophosphate useful to treat hepatitis C viral infections | UMPS, NUDT14, PNP | HSD17B10 3101/4885KMT2A 4136/4885HTT 3907/4885 |
| US-20240067657-A1 | AMIDO-SUBSTITUTED PYRIDYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES | TLR7, MALT1, PNPO | HSD17B10 2630/4885KMT2A 1388/4885HTT 4433/4885 |
| US-20120129875-A1 | SUBSTITUTED QUINAZOLINES AS FUNGICIDES | NAT1, NQO2, NOX1 | HSD17B10 2259/4885KMT2A 2145/4885HTT 2814/4885 |
| US-20170334942-A1 | DERIVATIVES OF URIDINE 5'-CYCLOPHOSPHATE USEFUL TO TREAT HEPATITIS C VIRAL INFECTIONS | UMPS, NUDT14, PNP | HSD17B10 3073/4885KMT2A 4097/4885HTT 3813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.