SCHEMBL8771904

SCHEMBL8771904

CC(COc1ccccn1)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 1/20 0.46
HPGD P15428 1/20 0.46
HTT P42858 1/20 0.46
CTSS P25774 1/20 0.44
CTSK P43235 1/20 0.44
TRPA1 O75762 1/20 0.44
CA2 P00918 1/20 0.42
BACE1 P56817 2/20 0.42
GLS O94925 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
ATM Q13315 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9225737 0.83 TSHR (0.41) ALDH1A1KDM4EHPGDHTTCTSS
SCHEMBL17491994 0.78 PPARA (0.56) CTSSCTSK
SCHEMBL17491998 0.78 PPARA (0.56) CTSSCTSK
SCHEMBL7362226 0.77 ALDH1A1 (0.62) ALDH1A1CTSSCTSKCA2BACE1
SCHEMBL25263870 0.77 KLK5 (0.45) CTSSCTSK
SCHEMBL25263868 0.77 KLK5 (0.45) CTSSCTSK
SCHEMBL8772006 0.76 CTSS (0.47) CTSSCTSKTRPA1CA2
SCHEMBL8771955 0.76 CTSS (0.44) ALDH1A1KDM4EHPGDHTTCTSS
SCHEMBL8772014 0.76 CTSK (0.53) CTSSCTSKTRPA1CA2
SCHEMBL25075422 0.75 TRPA1 (0.46) ALDH1A1KDM4EHPGDHTTTRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648740-B1 AMINO ACID AMIDE DERIVATIVE, AGROHORTICULTURAL BACTERICIDE, AND PRODUCTION PROCESS KUMIAI CHEMICAL INDUSTRY CO (JP) 1997-10-08 EP disclosed
EP-0648740-A1 AMINO ACID AMIDE DERIVATIVE, AGROHORTICULTURAL BACTERICIDE, AND PRODUCTION PROCESS KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-04-19 EP disclosed