Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 9/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772160 | 1.00 | LTB4R (0.47) | LTB4RSLC7A5LOXL2PARP1CYP4F2 | |
| SCHEMBL8772170 | 0.88 | LTB4R (0.48) | LTB4RCYP4F2CYP4A11 | |
| SCHEMBL8772180 | 0.88 | LTB4R (0.48) | LTB4RCYP4F2CYP4A11 | |
| SCHEMBL6330723 | 0.77 | LOXL2 (0.58) | SLC7A5LOXL2PARP1CYP4F2CYP4A11 | |
| SCHEMBL8772207 | 0.77 | LOXL2 (0.44) | SLC7A5LOXL2CYP4F2CYP4A11CYSLTR1 | |
| SCHEMBL9359858 | 0.76 | CYP4F2 (0.54) | SLC7A5LOXL2CYP4F2CYP4A11ADRB2 | |
| SCHEMBL5662355 | 0.76 | LOXL2 (0.51) | SLC7A5LOXL2CYP4F2CYP4A11ADRB2 | |
| SCHEMBL8772253 | 0.74 | NOS1 (0.44) | LTB4RADRB2CYSLTR1CDK8 | |
| SCHEMBL8772241 | 0.74 | NOS1 (0.44) | LTB4RADRB2CYSLTR1CDK8 | |
| SCHEMBL8772280 | 0.74 | LTB4R (0.81) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801061-A2 | Leucotrien-B4 derivatives, process for their preparation and their use as medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5614634-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5440044-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | disclosed |
| EP-0477311-A1 | NEW LEUCOTRIENE B 4? DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USE AS DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-04-01 | — | — | EP | disclosed |
| WO-1991014676-A1 | NEW LEUCOTRIENE B4 DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USE AS DRUGS | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-10-03 | — | — | WO | disclosed |