Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310067 | 0.78 | RAB9A (0.44) | LOXL2CYP4F2CYP4A11SLC7A5CYSLTR1 | |
| SCHEMBL8772160 | 0.77 | LTB4R (0.47) | LOXL2CYP4F2CYP4A11SLC7A5CYSLTR1 | |
| SCHEMBL8772152 | 0.77 | LTB4R (0.47) | LOXL2CYP4F2CYP4A11SLC7A5CYSLTR1 | |
| SCHEMBL30106103 | 0.76 | ALDH1A1 (0.41) | CYP4F2CYP4A11RAB9APOLBNPC1 | |
| SCHEMBL15709960 | 0.76 | ALDH1A1 (0.41) | CYP4F2CYP4A11RAB9APOLBNPC1 | |
| SCHEMBL7530273 | 0.75 | LOXL2 (0.51) | LOXL2CYP4F2CYP4A11RAB9APOLB | |
| SCHEMBL31346174 | 0.75 | LOXL2 (0.56) | LOXL2CYP4F2CYP4A11SLC7A5RAB9A | |
| SCHEMBL1505193 | 0.75 | LOXL2 (0.56) | LOXL2CYP4F2CYP4A11SLC7A5RAB9A | |
| SCHEMBL30107993 | 0.74 | CDK8 (0.54) | LOXL2RAB9ANPC1TSHRCDK8 | |
| SCHEMBL34953 | 0.73 | TSHR (0.70) | LOXL2CYP4F2CYP4A11SLC7A5RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801061-A2 | Leucotrien-B4 derivatives, process for their preparation and their use as medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5614634-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5440044-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | disclosed |
| EP-0477311-A1 | NEW LEUCOTRIENE B 4? DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USE AS DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-04-01 | — | — | EP | disclosed |
| WO-1991014676-A1 | NEW LEUCOTRIENE B4 DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USE AS DRUGS | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-10-03 | — | — | WO | disclosed |