Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27494325 | 0.89 | LMNA (0.45) | TP53LMNAPLAAT3PLAAT5PLAAT2 | |
| SCHEMBL8772502 | 0.83 | ALOX5 (0.42) | TP53PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL8102633 | 0.82 | TRPV1 (0.49) | LMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL8772392 | 0.81 | PLAAT3 (0.46) | TP53LMNAMAPTPLAAT3PLAAT5 | |
| SCHEMBL27495131 | 0.80 | KMT2A (0.45) | POLBKMT2AALDH1A1MEN1 | |
| SCHEMBL8439366 | 0.80 | LMNA (0.47) | TP53LMNAMAPTPLAAT3PLAAT5 | |
| SCHEMBL8772447 | 0.79 | LMNA (0.45) | TP53LMNAPLAAT3PLAAT5PLAAT2 | |
| SCHEMBL8772503 | 0.79 | TRPV1 (0.48) | LMNAKMT2AALDH1A1 | |
| SCHEMBL8438732 | 0.79 | TRPV1 (0.48) | LMNAKMT2AALDH1A1 | |
| SCHEMBL8442084 | 0.79 | TRPV1 (0.48) | LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1175246-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| CN-1175246-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |