Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL10591785 | 0.98 | NOS2 (0.58) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL15041111 | 0.81 | NOS2 (0.58) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL4646866 | 0.81 | NOS2 (0.58) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL9062832 | 0.80 | NOS1 (0.68) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| Iodide SCHEMBL11389805 | 0.79 | NOS3 (0.56) | NOS2GRIN2BGRIN1HRH4HRH3 | |
| Bromide SCHEMBL11806754 | 0.79 | NOS2 (0.59) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL14291059 | 0.77 | NOS2 (0.96) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL20675953 | 0.77 | NOS2 (0.96) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL10516683 | 0.77 | HTR3A (0.66) | NOS2GRIN2BGRIN1HRH4HRH3 | |
| SCHEMBL45769 | 0.76 | GRIN2B (0.68) | NOS2GRIN2BGRIN1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625967-B1 | N,N'-SUBSTITUTED IMIDOCARBONIMIDIC DIAMIDES DERIVED FROM HYDROXYLAMINES | JACOBUS PHARMA CO INC (US) | 1997-08-27 | — | — | EP | disclosed |
| WO-1995028377-A1 | GUANIDINE COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-10-26 | — | — | WO | disclosed |
| EP-0625967-A1 | N,N'-SUBSTITUTED IMIDOCARBONIMIDIC DIAMIDES DERIVED FROM HYDROXYLAMINES. | JACOBUS PHARMA CO INC (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5322858-A | Antimicrobial, antiparasitic agents | JACOBUS PHARMACEUTICAL CO. INC. (US) | 1994-06-21 | — | — | US | disclosed |
| WO-1993016037-A1 | N,N'-SUBSTITUTED IMIDOCARBONIMIDIC DIAMIDES DERIVED FROM HYDROXYLAMINES | JACOBUS PHARMACEUTICAL CO., INC. (US) | 1993-08-19 | — | — | WO | disclosed |