Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 5/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14005615 | 0.81 | HPGDS (0.58) | HPGDSCTRB1PIN1CTSLGPR132 | |
| SCHEMBL6929977 | 0.75 | HPGDS (0.52) | HPGDSCTRB1PIN1CTSLGPR132 | |
| SCHEMBL3497782 | 0.75 | GPR132 (0.70) | HPGDSGPR132 | |
| SCHEMBL28592116 | 0.75 | GPR132 (0.70) | HPGDSGPR132 | |
| SCHEMBL6929416 | 0.74 | HPGDS (0.58) | HPGDSCTRB1GPR132KDM4EALDH1A1 | |
| SCHEMBL6931268 | 0.74 | HPGDS (0.58) | HPGDSCTRB1GPR132KDM4EALDH1A1 | |
| SCHEMBL6925409 | 0.74 | HPGDS (0.58) | HPGDSCTRB1GPR132KDM4EALDH1A1 | |
| SCHEMBL28526144 | 0.74 | CTSL (0.82) | HPGDSCTRB1PIN1CTSLGPR132 | |
| SCHEMBL28526145 | 0.74 | CTSL (0.82) | HPGDSCTRB1PIN1CTSLGPR132 | |
| SCHEMBL7384250 | 0.73 | CTRB1 (0.64) | CTRB1CTSLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801640-A1 | 2,5-DIAMINO-3,4-DISUBSTITUTED-1,6-DIPHENYLHEXANE ISOSTERES COMPRISING BENZAMIDE, SULFONAMIDE AND ANTHRANILAMIDE SUBUNITS AND METHODS OF USING SAME | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) | 1997-10-22 | — | — | EP | disclosed |