Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 3/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.36 |
| ▸ | FEN1 | P39748 | 4/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774995 | 0.93 | RARB (0.46) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL8774917 | 0.91 | RARB (0.51) | NPC1RAB9ASMN1; SMN2HSD17B10RARB | |
| SCHEMBL8774831 | 0.90 | RARB (0.53) | NPC1RAB9ASMN1; SMN2HSD17B10RARB | |
| SCHEMBL8774251 | 0.90 | RARB (0.53) | NPC1RAB9ASMN1; SMN2HSD17B10RARB | |
| SCHEMBL8775178 | 0.90 | FEN1 (0.38) | GRM2ALOX5APFEN1GRIN2BGRIN1 | |
| SCHEMBL8774882 | 0.85 | RAB9A (0.41) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL9159847 | 0.84 | RARB (0.41) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL9512294 | 0.80 | RARB (0.51) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL10603849 | 0.80 | RARB (0.51) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL9879667 | 0.80 | RARB (0.46) | NPC1TP53PKMRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |