Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 4/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EIF4A1 | P60842 | 3/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8775053 | 0.96 | RARB (0.48) | RARBCTRCRARARARGMAPT | |
| SCHEMBL8774679 | 0.94 | RARB (0.50) | RARBRARARARGMAPTRAB9A | |
| SCHEMBL8774007 | 0.91 | RAB9A (0.42) | RARBCTRCRARARARGMAPT | |
| SCHEMBL8774855 | 0.87 | RARB (0.46) | RARBCTRCRARARARGMAPT | |
| SCHEMBL8774685 | 0.85 | RARB (0.45) | RARBCTRCRARARARGMAPT | |
| SCHEMBL8774744 | 0.85 | GCGR (0.38) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8775089 | 0.84 | GPR84 (0.36) | RARBCTRCRARARARGMAPT | |
| SCHEMBL8775095 | 0.84 | GPR84 (0.36) | RARBCTRCRARARARGMAPT | |
| SCHEMBL8774400 | 0.83 | RARB (0.36) | RARBCTRCRARARARGMAPT | |
| SCHEMBL8774407 | 0.83 | RARB (0.36) | RARBCTRCRARARARGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |