Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.45 |
| ▸ | RELA | Q04206 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774662 | 0.95 | RAB9A (0.46) | SMN1; SMN2RAB9ANFKB1NPC1NFKB2 | |
| SCHEMBL12430744 | 0.93 | RAB9A (0.42) | SMN1; SMN2RAB9ANFKB1NPC1NFKB2 | |
| SCHEMBL8774683 | 0.90 | RAB9A (0.40) | SMN1; SMN2RAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL8774856 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPK1 | |
| SCHEMBL8774499 | 0.86 | TAAR1 (0.39) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL8774425 | 0.85 | RAB9A (0.46) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPK1 | |
| SCHEMBL8774724 | 0.84 | AKR1C2 (0.50) | SMN1; SMN2RAB9ANFKB1NPC1NFKB2 | |
| SCHEMBL10282386 | 0.82 | ALDH1A1 (0.44) | SMN1; SMN2RAB9ANPC1MAPK1ALDH1A1 | |
| SCHEMBL8774078 | 0.81 | LMNA (0.47) | SMN1; SMN2RAB9ANFKB1NPC1NFKB2 | |
| SCHEMBL8774190 | 0.81 | ALDH1A1 (0.51) | SMN1; SMN2RAB9AL3MBTL1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |