Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9069480 | 0.89 | SRD5A2 (0.35) | NPC1RAB9APNMTHTR2BCYP1A2 | |
| Hydrochloric Acid SCHEMBL9069123 | 0.86 | SRD5A2 (0.35) | NPC1RAB9APNMTSRD5A2PGR | |
| SCHEMBL698266 | 0.79 | NPC1 (0.39) | NPC1RAB9APNMTHTR2BCYP1A2 | |
| Hydrochloric Acid SCHEMBL27425148 | 0.78 | PNMT (0.42) | NPC1RAB9APNMTHTR2BMAOA | |
| SCHEMBL27348144 | 0.77 | PNMT (0.45) | NPC1RAB9APNMTHTR2BMAOA | |
| Hydrochloric Acid SCHEMBL8776350 | 0.77 | NPC1 (0.37) | NPC1RAB9APNMTHTR2BCYP1A2 | |
| Hydrochloric Acid SCHEMBL8776359 | 0.77 | NPC1 (0.37) | NPC1RAB9APNMTHTR2BCYP1A2 | |
| Hydrochloric Acid SCHEMBL617844 | 0.77 | NPC1 (0.37) | NPC1RAB9APNMTHTR2BCYP1A2 | |
| Hydrochloric Acid SCHEMBL4447246 | 0.77 | DRD2 (0.38) | NPC1RAB9APNMTHTR2BCYP1A2 | |
| Hydrochloric Acid SCHEMBL7913247 | 0.77 | PNMT (0.36) | NPC1RAB9APNMTHTR2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628574-B1 | Olefin polymerization catalyst and olefin polymerization process | TOSOH CORP (JP) | 1997-12-03 | — | — | EP | disclosed |
| EP-0457291-B1 | Syndiotactic propylene copolymer, method for preparing same, and its use | MITSUI TOATSU CHEMICALS (JP) | 1996-11-27 | — | — | EP | disclosed |
| EP-0476148-B1 | PROPYLENE COPOLYMER | MITSUI TOATSU CHEMICALS (JP) | 1995-08-23 | — | — | EP | disclosed |
| EP-0459264-B1 | Method for preparing syndiotactic poly (alpha-olefin) | MITSUI TOATSU CHEMICALS (JP) | 1995-02-08 | — | — | EP | disclosed |
| US-5374685-A | Syndiotactic propylene copolymer, method for preparing same, and its use | MITSUI TOATSU CHEMICALS, INC. (JP) | 1994-12-20 | — | — | US | disclosed |
| EP-0628574-A1 | Olefin polymerization catalyst and olefin polymerization process | TOSOH CORPORATION (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5373059-A | Syndiotactic propylene copolymer, method for preparing same, and its use | MITSUI TOATSU CHEMICALS, INC. (JP) | 1994-12-13 | — | — | US | disclosed |
| US-5326824-A | Syndiotactic propylene copolymer, method for preparing same, and its use | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-07-05 | — | — | US | disclosed |
| US-5219968-A | PROPYLENE COPOLYMER | MITSUI TOATSU CHEMICALS, INC. (JP) | 1993-06-15 | — | — | US | disclosed |
| EP-0476148-A1 | PROPYLENE COPOLYMER | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-03-25 | — | — | EP | disclosed |
| EP-0459264-A2 | Method for preparing syndiotactic poly (alpha-olefin) | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-12-04 | — | — | EP | disclosed |
| EP-0457291-A2 | Syndiotactic propylene copolymer, method for preparing same, and its use | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-11-21 | — | — | EP | disclosed |