Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 8/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087025 | 0.88 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL8776720 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1NPSR1CNR1CNR2 | |
| SCHEMBL8776825 | 0.84 | PTGS2 (0.46) | PTGS2RORCPTGS1CNR1CNR2 | |
| SCHEMBL8776847 | 0.81 | CNR1 (0.52) | CYP1A2CYP2C9CYP2C19NPSR1CNR1 | |
| SCHEMBL8776822 | 0.79 | PTGS2 (0.56) | PTGS2PTGS1NPSR1CNR1CNR2 | |
| SCHEMBL2932218 | 0.79 | CNR1 (0.49) | CYP1A2CYP2C9CYP2C19NPSR1CNR1 | |
| SCHEMBL8093828 | 0.79 | CNR1 (0.52) | PTGS1CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL8776895 | 0.78 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL8776719 | 0.78 | PTGS2 (0.44) | PTGS2RORCPTGS1NPSR1CNR1 | |
| SCHEMBL8776742 | 0.77 | PTGS2 (0.54) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |