Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 9/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | ACR | P10323 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779161 | 0.96 | SMPD1 (0.39) | CYP1A2CYP2D6SMN1; SMN2HDAC6FAAH | |
| SCHEMBL8779132 | 0.94 | ACACB (0.34) | FAAHMAPTCA12CA1CA2 | |
| SCHEMBL8779296 | 0.89 | MEN1 (0.33) | KMT2A | |
| SCHEMBL8779424 | 0.89 | MAPK8 (0.37) | KDM4ESMN1; SMN2KMT2AMAPT | |
| SCHEMBL8779185 | 0.86 | ACACB (0.37) | KMT2A | |
| SCHEMBL8779211 | 0.85 | MEN1 (0.40) | KDM4ECYP1A2SMN1; SMN2KMT2AMAPT | |
| SCHEMBL8779357 | 0.84 | GPR88 (0.32) | — | |
| SCHEMBL8779178 | 0.83 | PRKD3 (0.33) | KDM4ESMN1; SMN2MAPTCA2SMPD1 | |
| SCHEMBL8786050 | 0.82 | MEN1 (0.38) | PDE4AFAAHKMT2AMAPTSMPD1 | |
| SCHEMBL8779309 | 0.81 | L3MBTL1 (0.39) | CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |